Osmotic Swelling Activates Intermediate-Conductance Cl- Channels in Human Intestinal Epithelial Cells.
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چکیده
منابع مشابه
Osmotic swelling-provoked release of organic osmolytes in human intestinal epithelial cells.
Human Intestine 407 cells respond to osmotic cell swelling by the activation of Cl(-)- and K(+)-selective ionic channels, as well as by stimulating an organic osmolyte release pathway readily permeable to taurine and phosphocholine. Unlike the activation of volume-regulated anion channels (VRAC), activation of the organic osmolyte release pathway shows a lag time of approximately 30-60 s, and i...
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Chloride release from nonpigmented ciliary epithelial (NPE) cells is a final step in forming aqueous humor, and adenosine stimulates Cl(-) transport by these cells. Whole cell patch clamping of cultured human NPE cells indicated that the A(3)-selective agonist 1-deoxy-1-(6-[([3-iodophenyl]methyl)amino]-9H-purin-9-yl)-N-methyl-be ta-D-ribofuranuronamide (IB-MECA) stimulated currents (I(IB-MECA))...
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Previous data indicate that adenosine 3',5'-cyclic monophosphate activates the epithelial basolateral Na+-K+-Cl-cotransporter in microfilament-dependent fashion in part by direct action but also in response to apical Cl- loss (due to cell shrinkage or decreased intracellular Cl-). To further address the actin dependence of Na+-K+-Cl-cotransport, human epithelial T84 monolayers were exposed to a...
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Necturus gallbladder epithelial cells bathed in 10 mM HCO3/1% CO2 display sizable basolateral membrane conductances for Cl- (GClb) and K+ (GKb). Lowering the osmolality of the apical bathing solution hyperpolarized both apical and basolateral membranes and increased the K+/Cl- selectivity of the basolateral membrane. Hyperosmotic solutions had the opposite effects. Intracellular free-calcium co...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 1994
ISSN: 0021-521X
DOI: 10.2170/jjphysiol.44.403